In Memory of Thomas R. Ten Have


Dear Friends,

It is with great sadness that I report on the death of our friend and colleague, Tom Ten Have. Tom was a devoted husband, father, professor, statistical scientist, and a beloved colleague. Tom was 50 years old. In his distinguished career he published over 200 wonderful peer reviewed papers that established new trajectories for statistical research and scientific thinking. Tom was a fellow of the American Statistical Association and a recipient of the Harvard Award for Lifetime Contributions to Psychiatric Epidemiology and Biostatistics.

Tom's methodological contributions have reduced bias in investigating treatment mechanism in comparative effectiveness studies of such outcomes as suicide and depression. Additional contributions focus on incorporating the results of these evaluations in designs of studies tailoring treatment to better relate to practice. His contributions represent a unique melding of leadership in methodological development with co-leadership on clinical and health services studies and scientific boards.

A major contribution has been the translation of clinically proven treatments to the community for such outcomes as suicide behavior and depression through behavioral interventions that improve the use and therefore the effectiveness of such treatments. Accordingly, Tom focused on integrating both new designs and methods of analysis in understanding the complexities of these interventions and their impact on patient behaviors such as non-adherence and drop-out that are more prevalent in the community. The new designs involve accommodating patient preferences and community barriers to minimize their impact on bias and thus improve the effectiveness of the treatments. The new analytic techniques focus on accounting for the negative effects of these behaviors and barriers in obtaining accurate causal estimates of treatment effectiveness. Moreover, Tom developed new causal techniques for understanding the process components of these complex interventions in an attempt to make them more robust and cost-effective.

Tom was frequently called upon by the Institute of Medicine of the National Academy of Sciences to be a valued member of their committees. Tom is particularly well remembered by IOM scientists and staff for his statistical leadership on the Committees on Review of the Bioastronautics Critical Path Roadmap, and Aerospace Medicine and the Medicine of Extreme Environments.

A sampling of Tom's wonderfully creative statistical contributions is contained in the following:


Mixed effects logistic regression models for longitudinal ordinal functional response data with multiple cause drop-out from the longitudinal study of aging.
Ten Have, T.R., Miller, M.E., Reboussin, B.A., and James, M.K.
Biometrics, Vol. 56, pp. 279–287, 2000.


Causal logistic models for non-compliance under randomized treatment with univariate binary response.
Ten Have, T.R., Joffe, M.M., and Cary, M.
Statistics in Medicine, Vol. 22, pp. 1255–1284, 2003.

Research to improve the quality of care for depression: alternatives to the simple randomized clinical trial.
Ten Have, T.R., Coyne, J.C., Salzer, M., and Katz, I.R.
General Hospital Psychiatry, Vol. 25, pp. 115–123, 2003.
Causal models for randomized physician encouragement trials in treating primary care depression.
Ten Have, T.R, Elliott, M., Joffe M., Zanutto, E. and Datto, C.
Journal of the American Statistical Association, Vol. 99, pp. 8–16, 2004.
A randomized trial to reduce suicidal ideation and depressive symptoms in depressed older primary care patients: The PROSPECT Study.
Bruce, M.L., Ten Have, T.R., Reynolds, C.F. III, Katz, I.R., Schulberg, H.C., Mulsant, B.H., Brown, G.K., McAvay, G.J., Pearson, J.L. and Alexopoulos, G.S.
Journal of the American Medical Association, Vol. 291, pp. 1081–1091, 2004.
Cognitive therapy for the prevention of suicide attempts: a randomized controlled trial.
Brown, G.K., Ten Have, T., Henriques, G.R., Xie, S.X., Hollander, J.E. and Beck, A.T.
Journal of the American Medical Association, Vol. 294, pp. 563–570, 2005.
Causal mediation analyses with rank preserving models.
Ten Have, T., Joffe, M., Lynch, K., Brown, G., Maistro, S. and Beck, A.
Biometrics, Vol. 63, pp. 926–934, 2007.

Intent-to-treat vs. Non-intent-to-treat Analyses under Treatment Non-adherence in Mental Health Randomized Trials.
Ten Have, T., Normand, S-L., Marcus, S., Brown, C.H., and Lavori, P.
Psychiatric Annals, Vol. 38, pp. 12–23, 2008.


Tom is survived by his wife Beth and daughter Anna.

In lieu of flowers, donations in Tom's memory can be made to either Philadelphia Futures, Philadelphia Collaborative Violence Prevention Center or ACHIEVEability.

We will miss him greatly.

Robert D. Gibbons

  Last updated July 2, 2015. Copyright © 2003-2015 Center for Health Statistics. All Rights Reserved.

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