In Memory of Thomas R. Ten
It is with great sadness that I report on the death of
our friend and colleague, Tom Ten Have. Tom was a devoted
husband, father, professor, statistical scientist, and a
beloved colleague. Tom was 50 years old. In his distinguished
career he published over 200 wonderful peer reviewed papers
that established new trajectories for statistical research
and scientific thinking. Tom was a fellow of the American
Statistical Association and a recipient of the Harvard Award
for Lifetime Contributions to Psychiatric Epidemiology and
Tom's methodological contributions have reduced bias
in investigating treatment mechanism in comparative effectiveness
studies of such outcomes as suicide and depression. Additional
contributions focus on incorporating the results of these
evaluations in designs of studies tailoring treatment to
better relate to practice. His contributions represent
a unique melding of leadership in methodological development
with co-leadership on clinical and health services studies
and scientific boards.
A major contribution has been the
translation of clinically proven treatments to the community
for such outcomes as suicide behavior and depression
through behavioral interventions that improve the use and
the effectiveness of such treatments. Accordingly, Tom
on integrating both new designs and methods of analysis
in understanding the complexities of these interventions
and their impact on patient behaviors such as non-adherence
and drop-out that are more prevalent in the community.
The new designs involve accommodating patient preferences
community barriers to minimize their impact on bias and
thus improve the effectiveness of the treatments. The
new analytic techniques focus on accounting for the negative
effects of these behaviors and barriers in obtaining
causal estimates of treatment effectiveness. Moreover,
Tom developed new causal techniques for understanding
components of these complex interventions in an attempt
to make them more robust and cost-effective.
Tom was frequently called upon by the Institute of Medicine
of the National Academy of Sciences to be a valued member
of their committees. Tom is particularly well remembered
by IOM scientists and staff for his statistical leadership
on the Committees on Review of the Bioastronautics Critical
Path Roadmap, and Aerospace Medicine and the Medicine of
A sampling of Tom's wonderfully creative statistical
contributions is contained in the following:
Mixed effects logistic
regression models for longitudinal ordinal functional response
data with multiple cause drop-out from the longitudinal
study of aging.
Ten Have, T.R., Miller, M.E.,
Reboussin, B.A., and James, M.K.
Vol. 56, pp. 279–287, 2000.
Causal logistic models
for non-compliance under randomized treatment with univariate
Ten Have, T.R., Joffe, M.M.,
and Cary, M.
in Medicine, Vol. 22, pp. 1255–1284, 2003.
|Research to improve the quality
of care for depression: alternatives to the simple randomized
Ten Have, T.R., Coyne, J.C.,
Salzer, M., and Katz, I.R.
General Hospital Psychiatry,
Vol. 25, pp. 115–123, 2003.
|Causal models for randomized
physician encouragement trials in treating primary care depression.
Ten Have, T.R, Elliott, M.,
Joffe M., Zanutto, E. and Datto, C.
Journal of the
American Statistical Association, Vol. 99, pp. 8–16,
|A randomized trial to reduce
suicidal ideation and depressive symptoms in depressed older
primary care patients: The PROSPECT Study.
Bruce, M.L., Ten Have, T.R.,
Reynolds, C.F. III, Katz, I.R., Schulberg, H.C., Mulsant,
B.H., Brown, G.K., McAvay, G.J., Pearson, J.L. and Alexopoulos,
Journal of the American Medical
Association, Vol. 291, pp. 1081–1091, 2004.
|Cognitive therapy for the
prevention of suicide attempts: a randomized controlled trial.
Brown, G.K., Ten Have, T.,
Henriques, G.R., Xie, S.X., Hollander, J.E. and Beck, A.T.
the American Medical Association, Vol. 294, pp. 563–570,
|Causal mediation analyses
with rank preserving models.
Ten Have, T., Joffe, M., Lynch,
K., Brown, G., Maistro, S. and Beck, A.
Vol. 63, pp. 926–934,
Intent-to-treat vs. Non-intent-to-treat
Analyses under Treatment Non-adherence in Mental Health
Ten Have, T., Normand,
S-L., Marcus, S., Brown, C.H., and Lavori, P.
Annals, Vol. 38, pp. 12–23, 2008.
Tom is survived by his
wife Beth and daughter Anna.
In lieu of flowers, donations in Tom's memory can be made
to either Philadelphia
Collaborative Violence Prevention Center or ACHIEVEability.
We will miss him greatly.
Robert D. Gibbons